NRL mission statement
The overall goal of research in Dr Bennett's laboratory is to make a difference in the lives of persons living with the devastating consequence of neurodegenerative disease. NRL researchers work to translate basic molecular mechanisms of neurodegeneration and neuroregeneration into new therapies. We focus on modulating cell membranes by targeting lipid metabolic enzymes, transporters, and integral membrane proteins to understand and treat Alzheimer's Disease, Parkinson's Disease, epilepsy, and pediatric diseases involving defective lipid metabolism. We use super-resolution imaging (stimulated emission depletion: STED), liquid chromatography electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS), induced pluripotent stem cell technology (iPSC), and transgenic mouse models of human disease to understand molecular mechanisms of brain cell injury and brain repair. We apply a lipidomics approach to identify biomarkers of disease progression and therapeutic efficacy. We work to repurpose existing drugs and plant-derived traditional medicines that alter lipid composition to effect neurological recovery. We believe that research brings hope and that biomedical neuroscience can improve the quality of life of persons suffering from intractable neurological disorders.